Expansion and Hepatic Differentiation of Adult Blood-Derived CD34+ Progenitor Cells and Promotion of Liver Regeneration After Acute Injury.
MouseChemical/toxinFVB-Tg(CAG-luc-eGFP)L2G85Chco/J donors; wild-type FVB recipients; mT/mG x albumin-Cre for mechanism studiesMalen = n = 10 per group, 20 recipient miceIntravenous via retro-orbital sinus2.5 x 10^6 cells in 150 microlitres salineOne day after CCl4
Model: Acute liver injury induced by CCl4 1.2 ml/kg diluted 1:1 in olive oil intraperitoneally
Intravenous dBDPCs given one day after CCl4 increased survival, restored body weight, lowered liver enzymes and necrosis, and promoted liver regeneration compared with saline.
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