Pharmacological evaluation of Mallotus philippinensis (Lam.) Muell.-Arg. fruit hair extract for anti-inflammatory, analgesic and hypnotic activity.
RatChemical/toxinCharles-Foster albinoEither sex; male only for the hypnotic studyn = n = 6 per groupOral100, 200 and 400 mg/kg, with 200 mg/kg optimal60 min before formalin, carrageenan or turpentine oil; 30 min before acetic aci…
Model: Carrageenan and formalin-induced paw oedema, turpentine oil-induced granuloma pouch, tail flick, hot plate and acetic acid writhing tests
The extract at 200 mg/kg inhibited formalin-induced paw oedema by 41.6% and carrageenan-induced oedema by 55.3% at 3 h, reduced granuloma weight by 29.6% and writhing by 45.7%, and raised pain thresholds.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.