Dopamine D1 receptor agonist A-68930 inhibits NLRP3 inflammasome activation and protects rats from spinal cord injury-induced acute lung injury.
RatSpinal cord injuryUnspecifiedSprague-DawleyfemaleAfter spinal cord injury, outcomes assessed 72 h post injury
Model: Spinal cord injury induced acute lung injury
A-68930 inhibited NLRP3 inflammasome activation, lowered proinflammatory cytokines and myeloperoxidase activity, and attenuated pulmonary oedema and lung histopathology at 72 h after spinal cord injury.
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