A synthetic biology-based device prevents liver injury in mice.
MouseChemical/toxinOF1Femalen = At least n = 5 per group for histologyIntraperitoneal implantation of alginate-poly-(L-lysine)-alginate beads; hepatotoxicant given orallyImplant present before hepatotoxicant challenge, responding automatically to ri…
Model: Drug-induced acute liver injury with alpha-naphthylisothiocyanate 75 mg/kg or CCl4 1 ml/kg as a single oral dose
Mice bearing the bile acid-sensing HGF-producing implant were protected from drug-induced liver failure, with lower ALT, serum bile acids and bilirubin and no histological necrosis compared with placebo implants.
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