Activated protein C protects against renal ischaemia/reperfusion injury, independent of its anticoagulant properties.
MouseIschaemia-reperfusionRenalC57BL/6jMaleIntraperitoneal200 micrograms/kg APC or mutant APC; blocking monoclonal an…
Model: Renal ischaemia and reperfusion injury
APC reduced tubular injury and improved renal function without altering inflammation, and the mutant lacking anticoagulant activity was equally protective, indicating the benefit is independent of anticoagulation.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.