Targeting coagulation factor XII as a novel therapeutic option in brain trauma.
MouseTBIWeight-drop / impact-accelerationC57BL/6N wild-type, FXII-deficient and FXI-deficient miceMale and femalen = 148 C57BL/6N wild-type mice (134 male, 14 female), 60 FXII-…Intravenous200 mg/kg body weightSingle bolus after injury induction; reconstitution experiments with human FXII…
Model: Weight-drop closed-head injury (concussion-like diffuse TBI) and cortical cryolesion
Both genetic factor XII deficiency and pharmacological inhibition of activated factor XII with rHA-Infestin-4 minimised trauma-induced microvascular thrombus formation and improved outcome, with better motor function, reduced brain lesion volume and diminished neurodegeneration, without increasing…
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