Blocking B7-1/CD28 Pathway Diminished Long-Range Brain Damage by Regulating the Immune and Inflammatory Responses in a Mouse Model of Intracerebral Hemorrhage.
MouseOtherICRMaleInner canthus venous plexus injection10 min and 24 h after intracerebral haemorrhage
Model: Experimental intracerebral haemorrhage
Anti-B7-1 antibody lowered immune function, reduced the interferon gamma to interleukin-4 ratio, shortened water maze latency on days 18 and 20, and reduced body weight on day 3, which the authors interpret as reduced long-range brain damage through reversal of immune imbalance.
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