Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice.

Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice.

Model: Transient middle cerebral artery occlusion for 60 min with an intraluminal thread, with hyperglycaemia induced by intraperitoneal dextrose 15 min before occlusion

Hyperglycaemia increased infarct volume (36.3 +/- 1.20 versus 26.9 +/- 1.28), oedema and haemorrhagic transformation. Exendin-4, but not insulin, reduced matrix metalloproteinase-9 activation, tumour necrosis factor alpha and oxidative stress markers, and reduced infarct volume at 24 h (23.6 +/- 0.…

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