Combination of microRNA-21 and microRNA-146a Attenuates Cardiac Dysfunction and Apoptosis During Acute Myocardial Infarction in Mice.
MouseIschaemia-reperfusionCardiacKunmingMaleIntramuscular injection into the left ventricular myocardium at multiple sitesagomiR-21 100 nmol/kg, agomiR-146a 100 nmol/kg, combination…24 h before coronary artery ligation
Model: Acute myocardial infarction by left anterior descending coronary artery ligation
Combined agomiR-21 and agomiR-146a reduced infarct size and cardiomyocyte apoptosis and improved ejection fraction and fractional shortening more than either microRNA alone. Infarction raised caspase-3 mRNA about 5.5-fold, caspase-3 activity about 3.0-fold and p-p38 MAPK 2.3-fold, all attenuated mo…
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