MG53 permeates through blood-brain barrier to protect ischemic brain injury.
MixedIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-Dawley rats; tPA-MG53 transgenic mice with littermate wild-type controlsn = n=7 per group for rat infarct size and neurological score;…Intravenous, via left external jugular vein catheter in rats, tail vein in the general protocol3 mg/kg body weight (single dose); 60 micrograms/ml for 2 h…30 min before ischaemia, immediately after ischaemia, or 1, 2, 4 or 6 h after r…
Model: Transient middle cerebral artery occlusion, 60 min occlusion followed by reperfusion for 24 h
A single intravenous dose of rhMG53 at 3 mg/kg given 30 min before ischaemia or up to 4 h after reperfusion reduced infarct area, improved Zea-Longa scores at 24 h, reduced TUNEL positivity and caspase-3 activation, and restored Akt and GSK3-beta phosphorylation. Benefit was lost when dosing was de…
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