A novel composite type I collagen scaffold with micropatterned porosity regulates the entrance of phagocytes in a severe model of spinal cord injury.
RatSpinal cord injuryComplete transectionSprague-DawleyFemaleImplantation into the resected spinal cord segmentAt the time of injury, immediately after segment resection
Model: Segment resection of the thoracic spinal cord (severe spinal cord injury)
The scaffold integrated with host tissue and limited inflammatory cell recruitment at the injury site during both acute and chronic stages, but locomotor function was only slightly improved.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.