Effect of Mitomycin C on bFGF, TGF-beta1, KGF-1 Expressions after Myringotomy: An Animal Study.
RatWoundWistar albinoMale and female (20 male and 20 female)n = 40 rats divided into five groupsTopical application to the right earAt the time of myringotomy
Model: Electrocautery myringotomy of the tympanic membrane (acute perforation)
Complete healing was significantly less frequent in the mitomycin C group than the saline group at days 7 and 14 (P<0.05). Growth factor expression was largely unchanged except for higher transforming growth factor beta1 in macrophages at day 3 in the mitomycin C group (P=0.001).
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