A hybrid microfluidic system for regulation of neural differentiation in induced pluripotent stem cells.
RatSpinal cord injuryHemisection / partialWistarFemaleImplantation of the cell-seeded scaffold into the hemisected spinal cordAcute phase, at the time of hemisection
Model: Acute spinal cord hemisection
Neuronal-specific gene expression was significantly higher on the microfluidic device than on control systems, and implanted cells survived and integrated, but this did not lead to significant locomotor recovery.
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