Botulinum Toxin Confers Radioprotection in Murine Salivary Glands.
MouseRadiationC57BL/6Femalen = n=6 per group; 50 female C57BL/6 mice in totalIntraglandular injection (direct injection into the exposed submandibular gland)3.75 mU/g injected into each submandibular glandPretreatment 48 to 72 hours before irradiation
Model: Focal single-dose irradiation of the submandibular glands (15 Gy total, 7.5 Gy per side, 225 kVp x-rays)
Botulinum toxin pretreatment limited the fall in stimulated saliva flow to about 25 per cent versus about 50 per cent in irradiated saline controls at 3 days, and preserved gland weight (20 per cent loss versus 40 per cent) and acinar surface area (46 per cent versus 28 per cent) at 4 weeks. Neutro…
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