Omega-3 Fatty Acid Protects Against Arsenic Trioxide-Induced Cardiotoxicity In Vitro and In Vivo.
MixedChemical/toxinWistarMaleCo-administration with arsenic trioxide (route not stated for omega-3; arsenic trioxide was given orally at 4 mg/kg)Co-administered with arsenic trioxide over the 45-day exposure period
Model: Arsenic trioxide-induced cardiotoxicity: 4 mg/kg body weight arsenic trioxide given orally for 45 days in vivo, with arsenic trioxide exposure of H9c2 cardiomyocytes in vitro
Arsenic trioxide increased tissue arsenic deposition, micronuclei frequency, creatine kinase-MB activity and lipid peroxidation, and lowered antioxidant enzyme levels. Omega-3 co-administration significantly alleviated these changes in vivo, and in vitro increased cardiomyocyte viability, reduced l…
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