Losartan attenuated lipopolysaccharide-induced lung injury by suppression of lectin-like oxidized low-density lipoprotein receptor-1.
RatEndotoxin/LPSSprague-DawleyMalen = 30 male Sprague-Dawley rats randomised across three groups
Model: Lipopolysaccharide-induced acute lung injury
Losartan significantly reduced the lipopolysaccharide-induced rise in bronchoalveolar lavage TNF-alpha and protein, lung myeloperoxidase activity, pulmonary oedema and lung injury score, and lowered LOX-1 mRNA and protein along with the LOX-1 mediated increases in caspase-3 and ICAM-1.
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