Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration.
MouseSpinal cord injuryUnspecifiedNestin-GFP transgenicApplied acutely after injury, for 4 hours or 8 hours
Model: Spinal cord injury at the thoracic T12 segment level
TSC1 treatment for 4 and 8 hours increased nestin-expressing cell numbers around the lesion and prevented Wallerian degeneration. Four hours of treatment significantly increased HSP-32 and HSP-70 expression 1 and 2 mm from the lesion; HSP-32 positive cell numbers fell after 8 hours of treatment but…
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