Targeted activation of CREB in reactive astrocytes is neuroprotective in focal acute cortical injury.
MouseTBIUnspecifiedC57BL/6 background bitransgenic (Tet-Off astrocyte-targeted VP16-CREB) and wild-type littermatesMale and femaleTransgenic expression, no exogenous administrationTransgene expressed before injury (constitutive, Tet-Off regulated)
Model: Focal acute cortical injury (experimental traumatic brain injury)
Bitransgenic mice expressing VP16-CREB in astrocytes showed less neuronal death and damage, reduced macrophage infiltration, preserved mitochondria and rescued expression of mitochondrial metabolism genes compared with wild-type littermates. A core set of candidate VP16-CREB target genes was identi…
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