MW151 Inhibited IL-1beta Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.
MouseTBIFluid percussionC57BL/6Malen = Dose response experiment: n=8 sham plus vehicle, n=12 injur…Intraperitoneal injection0.5, 1.5 or 5.0 mg/kg in the repeat dosing experiment; 5 mg…1 h and 3 h after injury in the repeat dosing experiment; 1 h after injury in t…
Model: Midline fluid percussion injury (diffuse axonal brain injury) of moderate severity at 1.2 plus or minus 0.05 atm
MW151 significantly suppressed injury-induced cortical IL-1 beta at all three doses (0.5 mg/kg p=0.0283, 1.5 mg/kg p=0.0049, 5 mg/kg p=0.0008), with maximal suppression at 1.5 mg/kg and no further gain at 5 mg/kg; a single 5 mg/kg dose at 1 h also suppressed IL-1 beta (p=0.0362). F4/80 and GFAP sta…
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