Gastroprotective Effects of Astragaloside IV against Acute Gastric Lesion in Rats.
RatOtherSprague-DawleyMalen = 48 rats in total, six groups of eightIntragastric gavage1, 10 or 50 mg/kg body weight, suspended in 10 per cent Twe…Pre-treatment 1 h before water immersion and restraint stress
Model: Acute gastric lesion induced by water immersion and restraint stress for 12 h in Bollman-type cages at 20 degrees C after a 24 h fast
Astragaloside IV dose-dependently reduced gastric lesion area from 860.82 plus or minus 12.47 in the lesion control to 705.64 (1 mg/kg, 18.03 per cent inhibition), 499.41 (10 mg/kg, 41.26 per cent) and 251.48 (50 mg/kg, 70.79 per cent), comparable with omeprazole 20 mg/kg (270.58, 68.57 per cent).…
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.