PRECLINICAL PUBLICATION · 2016

Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury.

Rat / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Adeno-associated virus vector expressing the astrocyte-specific Gfa2 promoter and the NFAT-inhibitory peptide VIVIT (AAV-Gfa2-VIVIT)

PMID 26843634 ↗2016Reported benefit

Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury.

RatTBIControlled cortical impactSprague-DawleyMale

Model: Controlled cortical impact traumatic brain injury

AAV-Gfa2-VIVIT prevented the injury-related loss of basal CA1 synaptic strength and key synaptic proteins, reduced susceptibility to long-term depression and increased SPARCL1 expression, without altering GFAP or Iba1 levels.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.