Wound healing and antimicrobial activity of two classical formulations of Laghupanchamula in rats.
MixedWoundCharles-Foster albino rats; Swiss albino miceEither sexn = n = 6 per groupOral, by oro-gastric tube, 1 ml per 100 g body weightDose-ranging at 500, 1000 and 1500 mg/kg in the incision mo…First dose 4 h after induction of the excision wound; dosing from day 1 in the…
Model: Two 6 cm paravertebral full-thickness incision wounds closed with interrupted sutures (incision model) and a full-thickness excision wound of approximately 500 mm2 on the back (excision model), both under ketamine 50 mg/kg anaesthesia
Both extracts at 1000 mg/kg significantly increased wound breaking strength (LPGE 563.3 +/- 16.3 g, LPEE 528.3 +/- 18.5 g versus control 400.0 +/- 11.5 g), accelerated contraction, shortened epithelisation (9.17 and 8.67 days versus 11.2 days) and reduced scar area, comparable with Vitamin E, and s…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.