Minocycline Transiently Reduces Microglia/Macrophage Activation but Exacerbates Cognitive Deficits Following Repetitive Traumatic Brain Injury in the Neonatal Rat.
RatTBIControlled cortical impactSprague-DawleyMale and femaleAcute administration after injury, exact interval not stated
Model: Repetitive impact traumatic brain injury modelling abusive head trauma, three impacts delivered 24 h apart in 11-day-old rats
Minocycline reduced microglial and macrophage reactivity in the corpus callosum at 3 days but not 7 days post-injury, had no effect on axonal injury, neurodegeneration or tissue atrophy, and exacerbated injury-induced spatial memory deficits.
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