Wortmannin, PI3K/Akt signaling pathway inhibitor, attenuates thyroid injury associated with severe acute pancreatitis in rats.
RatOtherSprague-DawleyMalen = 60 rats randomly divided into four groups
Model: Severe acute pancreatitis with associated thyroid injury, induced surgically (method of induction not stated in the available text)
Wortmannin reduced serum amylase, lipase and thyroid hormone disturbance, attenuated pancreatic and thyroid histological injury and ultrastructural change, lowered thyroid malondialdehyde and serum TNF-alpha, IL-6 and IL-1beta, and reduced AKT, p38 MAPK and NF-kappaB expression in thyroid tissue.
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