Comparison of two ester prodrugs of methylprednisolone on early neurologic recovery in a murine closed head injury model.
MouseTBIClosed-head / concussionCF-1MaleIntravenousU67590A 7.5 or 15.0 mg/kg produced significant improvement;…Within 5 min of injury
Model: 900 g-cm concussive closed head injury
Both methylprednisolone esters improved early neurological recovery after severe concussive head injury. U67590A was four to eight times more potent than MPSS, with equal maximal efficacy, indicating the ester moiety influences cerebroprotective potency.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.