PRECLINICAL PUBLICATION · 2016

Targeted delivery of human iPS-ECs overexpressing IL-8 receptors inhibits neointimal and inflammatory responses to vascular injury in the rat.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Human induced pluripotent stem cell derived endothelial cells overexpressing IL-8 receptors A and B (HiPS-IL8RA/B-ECs), generated using adenoviral vectors

PMID 26801304 ↗2016Reported benefit

Targeted delivery of human iPS-ECs overexpressing IL-8 receptors inhibits neointimal and inflammatory responses to vascular injury in the rat.

RatOtherSprague-DawleyMaleIntravenous transfusion1.5 x 10^6 cells per animalImmediately after endoluminal injury

Model: Balloon endoluminal injury of the right carotid artery

HiPS-IL8RA/B-ECs homed to the injured artery, reduced inflammatory mediator expression and inflammatory cell infiltration, accelerated re-endothelialisation and attenuated neointima formation, whereas control HiPS-ECs and HiPS-Null-ECs did not.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.