PRECLINICAL PUBLICATION · 2015

Oligonol Ameliorates CCl4-Induced Liver Injury in Rats via the NF-Kappa B and MAPK Signaling Pathways.

Rat / Chemical/toxin

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Oligonol, a low molecular weight polyphenol of catechin-type monomers and oligomers derived from lychee fruit

PMID 26798422 ↗2015Reported benefit

Oligonol Ameliorates CCl4-Induced Liver Injury in Rats via the NF-Kappa B and MAPK Signaling Pathways.

RatChemical/toxinSprague-Dawleyoral10 or 50 mg/kg

Model: Carbon tetrachloride (CCl4)-induced acute hepatic injury

Oral oligonol reduced CCl4-induced histological abnormalities and lowered serum AST and ALT, attenuated inflammatory mediator expression and suppressed NF-kappa B activation and upstream kinase phosphorylation.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.