Bortezomib alleviates drug-induced liver injury by regulating CYP2E1 gene transcription.
MouseChemical/toxinC57BL/6maleinjection; route not specified in the abstract1 mg/kg bortezomibadministered before acetaminophen treatment
Model: Acetaminophen-induced drug-induced liver injury, with additional carbon tetrachloride and thioacetamide hepatotoxicity models
Bortezomib alleviated acetaminophen, carbon tetrachloride and thioacetamide hepatotoxicity and reduced hepatic CYP2E1 expression and activity, whereas MG132 aggravated acetaminophen-induced injury.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.