PRECLINICAL PUBLICATION · 2016

Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy.

Mouse / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Sinomenine

PMID 26795599 ↗2016Reported benefit

Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy.

MouseOther

Model: Obstructive nephropathy (mouse model)

Sinomenine reduced kidney damage, inflammatory responses and renal oxidative stress in an Nrf2-dependent manner and modulated macrophage polarisation.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.