Beneficial effects of IL-37 after spinal cord injury in mice.
MouseSpinal cord injuryContusionhuman IL-37 transgenic (hIL-37tg) and wild-type micesingle intraspinal injectionafter the injury
Model: Spinal cord contusion injury
Transgenic hIL-37tg mice showed increased myelin and neuronal sparing, 2.5-fold greater forced treadmill speed and roughly 80 per cent lower IL-6 in the injured cord. A single intraspinal injection of either form of recombinant IL-37 into wild-type mice improved open field and treadmill locomotor p…
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