IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo.
MouseChemical/toxinIL-36R-deficient and Myd88-deficient miceapplied to established experimental intestinal wounds
Model: Acute dextran sodium sulfate colitis and experimental intestinal mucosal wounds
Defective IL-36R signalling increased susceptibility to dextran sodium sulfate colitis and impaired wound healing, while treating experimental intestinal wounds with IL-36R ligands significantly accelerated mucosal healing in vivo.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.