Epoxyeicosatrienoic acid analogue mitigates kidney injury in a rat model of radiation nephropathy.
RatRadiationWAG/RijCmcrMalen = 8 to 10 per groupOral, in drinking waterEET-A 10 mg/kg/day; comparator captopril 30 mg/kg/dayStarted 2 days after total body irradiation
Model: Total body irradiation, 11 Gy posterior to anterior at 1.75 Gy/min with hind leg shielding, causing radiation nephropathy
EET-A reduced azotaemia, albuminuria, hypertension, interstitial fibrosis and renal apoptosis after total body irradiation, with efficacy comparable to captopril.
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