Protective effect of mycophenolate mofetil against nephrotoxicity and hepatotoxicity induced by tacrolimus in Wistar rats.
RatChemical/toxinWistarmaleMycophenolate mofetil 50 mg/kg body weight; tacrolimus 60 m…co-administered with tacrolimus
Model: Tacrolimus-induced nephrotoxicity and hepatotoxicity at 60 mg/kg body weight
Co-administration of mycophenolate mofetil restored creatinine and reduced the tacrolimus-induced rise in AST and ALT, decreased DNA damage in kidney and liver, and lowered malondialdehyde and protein carbonyl levels together with changes in catalase and superoxide dismutase activities.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.