Bladder response to acute sacral neuromodulation while treating rats in different phases of complete spinal cord injury: a preliminary study.
RatSpinal cord injuryComplete transectionSprague-DawleyFemalen = 8 rats in total, approximately 1 per timepoint in this prel…Unilateral S1 sacral foramen electrodeMonophasic negative pulses, 20 Hz, 0.1 ms pulse width, 30 s…Tested at 7, 12, 15, 18, 20, 27, 36 and 42 days after transection
Model: Complete spinal cord transection at T9 to T10 after laminectomy, with gel foam packing
Acute sacral neuromodulation lengthened the intercontraction interval and contraction duration most markedly between about two and four weeks after transection, with much smaller effects in the spinal shock phase and in later chronic animals.
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