Proton Minibeam Radiation Therapy Reduces Side Effects in an In Vivo Mouse Ear Model.
MouseRadiationBALB/cFemaleExternal proton beam at the SNAKE ion microprobe16 minibeams of nominally 6000 Gy in a 4 x 4 array, each 0.…
Model: Radiation induced injury of the mouse ear from 20 MeV proton irradiation of a central 7.2 x 7.2 mm field
Proton minibeam irradiation caused no measurable ear swelling or skin reaction, whereas homogeneous irradiation at the same average dose produced up to fourfold swelling, erythema, desquamation and loss of sebaceous glands.
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