PRECLINICAL PUBLICATION · 2015

TREM-1-accentuated lung injury via miR-155 is inhibited by LP17 nanomedicine.

Mouse / Endotoxin/LPS

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

LP17 TREM-1 inhibitory peptide in nanomicelles; antagomir-155 used as a mechanistic tool

PMID 26684249 ↗2015Reported benefit

TREM-1-accentuated lung injury via miR-155 is inhibited by LP17 nanomedicine.

MouseEndotoxin/LPSC57BL/6, including TREM-1 knockout animalsMale

Model: Lipopolysaccharide induced acute lung injury with neutrophilic inflammation, including lethal LPS dosing for survival studies

TREM-1 deletion or nanomicellar LP17 inhibition improved survival after lethal LPS and abolished neutrophilic lung inflammation through reduced miR-155 and restored SOCS-1.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.