Vitamin D/VDR signaling attenuates lipopolysaccharide-induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier.
MouseEndotoxin/LPSC57BL/6J background, vitamin D receptor wild-type and knockoutMale and femalen = Two mice per sex per treatment group, that is about n = 4 p…Intraperitoneal0.5 ug/kg body weight in propylene glycol:ethanol 90:1030 min before LPS instillation
Model: Lipopolysaccharide-induced acute lung injury, Escherichia coli 0111:B4 LPS 10 mg/kg intratracheally, assessed 12 h later
Paricalcitol pretreatment reduced lung injury score, oedema, BALF protein and proinflammatory cytokine induction, and preserved occludin and ZO-1 expression, whereas VDR knockout mice showed more severe LPS-induced injury.
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