Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.
RatTBIControlled cortical impactSprague-DawleyMaleIntravenous10 mg/kg or 20 mg/kg15 min and 24 h after injury
Model: Three parallel models: parasagittal fluid percussion injury, controlled cortical impact and penetrating ballistic-like brain injury
Cyclosporin A at 10 mg/kg gave histological protection in the least severe model (fluid percussion injury), but 20 mg/kg worsened working memory in that model and impaired Morris water maze performance after controlled cortical impact, with increased mortality after penetrating ballistic-like brain…
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