Effect of administration of antibodies against nerve growth factor in a rat model of muscle injury.
RatCrushLimb / muscle crushSprague-DawleyMalen = 24 male rats in total, 12 receiving anti-NGFInjection into the injured muscle50 uL of anti-NGF antibody solution (concentration not stat…After induction of muscle injury (exact interval not stated)
Model: Drop-mass contusion injury of the right gastrocnemius muscle, with Fluoro-Gold retrograde tracing of sensory nerves
Anti-NGF antibody reduced muscle necrosis at 1 and 3 days, promoted granulation tissue replacement and muscle fibre regeneration by 7 days, and lowered the proportion of CGRP positive Fluoro-Gold labelled neurons (38.2% versus 49.6% in controls, P<0.05).
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.