The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD.
MouseChemical/toxinBALB/c wild-type and STAT6 knockoutAdoptive transfer of macrophages; systemic Wnt agonist administration
Model: 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced colitis with mucosal damage
STAT6 knockout mice showed impaired M2 macrophage gene expression, reduced Wnt ligand and beta-catenin signalling and delayed wound healing after TNBS. Transfer of properly polarised M2a macrophages, or a Wnt agonist, restored Wnt signalling in the damaged mucosa and accelerated wound healing.
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