Corticotropin-Releasing Hormone Receptor 2 Signaling Promotes Mucosal Repair Responses after Colitis.
MouseChemical/toxinICR background and CRHR2 knockout miceMaleIntracolonic injectionAfter DSS-induced colitis, during the healing phase
Model: Dextran sodium sulfate induced colitis, studied during the mucosal healing phase after DSS withdrawal
CRHR2 antagonism after DSS colitis increased disease activity, delayed healing, reduced epithelial proliferation and increased apoptosis and proinflammatory cytokine expression, and CRHR2 knockout mice showed increased mortality, supporting CRHR2 activation rather than blockade as the repair-promot…
Extraction: extract · Supplied extraction confidence: 0.4. Machine-extracted fields require source verification.