Bone marrow mesenchymal stem cell aggregate: an optimal cell therapy for full-layer cutaneous wound vascularization and regeneration.
RatWoundSprague-Dawley hosts with GFP-transgenic Sprague-Dawley donorsFemale hostsn = 96 female host rats in 6 groups, 6 excluded for acute infec…Aggregate laid on the wound bed under SIS membrane and Tegaderm; topical arm subcutaneous at four sites 3 mm from the wound rim; intravenous arm via the caudal veinOne aggregate per wound containing on average 1.35 (SD 0.07…Immediately after wounding, within 30 s of injury
Model: Acute full-thickness (full-layer) excisional cutaneous wound, 2 cm diameter, on the dorsum with panniculus carnosus removed
Aggregate transplantation gave the smallest residual wound area at 4 weeks (6.43% of original versus 13.12% topical and 13.10% intravenous), the highest capillary density and more regular collagen, together with a shorter inflammatory phase and greater GFP-positive cell engraftment. All three cell-…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.