Dopamine treatment attenuates acute kidney injury in a rat model of deep hypothermia and rewarming - The role of renal H2S-producing enzymes.
RatOtherWistarMalen = n >= 5 per groupContinuous infusionInfused throughout the cooling and rewarming procedure
Model: Deep hypothermia to a body temperature of 15 C for 3 h followed by 1 h of rewarming under anaesthesia, producing acute kidney injury
Hypothermia and rewarming raised serum creatinine, renal reactive oxygen species, KIM-1 and immune cell influx while lowering renal H2S-producing enzyme expression and serum H2S. Dopamine infusion fully attenuated renal damage and maintained enzyme expression and serum H2S, whereas amino-oxyacetic…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.