Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse.
MouseTBIControlled cortical impactC57Bl/6JMalen = 112 mice in total; n = 15 per group for long-term behaviour…Subcutaneous25 mg/kg per injection, formulated at 5.0 mg/mL in 65% prop…First dose 2 h post-injury, treatment confined to the first 48 h
Model: Controlled cortical impact traumatic brain injury after craniotomy, 4.5 m/s, 1.73 mm depth, 150 ms sustained depression, 3.0 mm convex tip; sham mice had craniotomy only
Active and pro forms of MMP-2 and MMP-9 were elevated at 48 h and p-OH SB-3CT crossed the blood-brain barrier at therapeutic concentrations and attenuated in situ gelatinase activity, yet it did not alter hyperactivity, water maze deficits, reduced sociability, tissue loss, surviving dentate neuron…
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