Therapeutic effects of late outgrowth endothelial progenitor cells or mesenchymal stem cells derived from human umbilical cord blood on infarct repair.
RatIschaemia-reperfusionCardiacSprague-Dawley for functional studies and nude rats for mechanistic studiesmaleintramyocardial injection into the border zone of the ischaemic heart5 x 10^5 EPC or MSC in 50 microlitres of phosphate buffered…1 h after myocardial infarction
Model: Myocardial infarction by ligation of the left anterior descending coronary artery
Both late endothelial progenitor cells and mesenchymal stem cells improved ejection fraction, fractional shortening, wall thickness and capillary density and reduced apoptosis compared with vehicle, with fibrosis reduced only in the endothelial progenitor cell group.
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