Use of Arctium lappa Extract Against Acetaminophen-Induced Hepatotoxicity in Rats.
RatChemical/toxinSprague-Dawleymalen = 48 rats in 4 groupsoral300 mg/kg body weight (300 mg/mL in saline)
Model: Acetaminophen-induced hepatotoxicity, single oral dose of acetaminophen 800 mg/kg
Arctium lappa extract lowered plasma ALT, AST and ALP, reduced malondialdehyde and DNA migration and limited histological damage after acetaminophen overdose, although reduction of necrosis was incomplete.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.