Neuromuscular Blocking Agent Cisatracurium Attenuates Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-alpha1.
RatChemical/toxinSprague-Dawleymalen = 10 rats per group across 4 groupsgiven during the 3 h of mechanical ventilation after acid instillation
Model: Acute lung injury by intratracheal instillation of hydrogen chloride followed by mechanical ventilation at tidal volume 6 mL/kg and PEEP 8 cm H2O for 3 h
Cisatracurium and pancuronium improved respiratory compliance and oxygenation and lowered plasma tumour necrosis factor alpha and interleukin 6 after acid-induced lung injury, with the anti-inflammatory effect reproduced by silencing nicotinic acetylcholine receptor alpha1 in human cells.
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