Role of G-CSF in monophosphoryl lipid A-mediated augmentation of neutrophil functions after burn injury.
MouseBurnUnspecifiedBALB/cprophylactic treatment given after burn injury and before infection
Model: Burn injury followed by Pseudomonas aeruginosa burn wound infection and sepsis
Monophosphoryl lipid A mobilised neutrophils from bone marrow to blood and to the infection site, improved bacterial clearance and improved survival after burn wound infection, and all of these benefits were abolished by G-CSF neutralisation.
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