Radioprotective Properties of Indralin in Combination with Monizol in the Treatment of Local Acute and Delayed Radiation Injuries Caused by Local Skin gamma-Irradiation.
RatRadiationFemaleIndralin per os; monizol intraperitonealIndralin 15 min before irradiation; monizol 5 min after irradiation
Model: Local gamma-irradiation of the right hindpaw at 30 to 50 Gy, dose rate 131 to 154 cGy/min
Indralin was radioprotective against both acute and delayed local radiation injury, and combination with monizol potentiated the effect to a dose reduction factor of 1.4 to 1.5 for both burn severity and prevention of contracture and limb amputation.
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