Blockade of Interplay between IL-17A and Endoplasmic Reticulum Stress Attenuates LPS-Induced Lung Injury.
MouseEndotoxin/LPSC57BL/6Femalen = 5 or 6 mice in each groupAnti-IL-17A intraperitoneal; 4-phenylbutyrate intraperitoneal; TAK-242 intravenousAnti-IL-17A 5 mg/kg body weight per day; 4-phenylbutyrate 2…Anti-IL-17A 6 h before and 6 h after LPS; 4-phenylbutyrate 1 h before and 6, 18…
Model: Single intratracheal instillation of 50 micrograms lipopolysaccharide in 50 microlitres saline under inhaled isoflurane anaesthesia
Anti-IL-17A antibody and 4-phenylbutyrate each reduced LPS-induced bronchoalveolar inflammatory cell influx, vascular leakage, myeloperoxidase activity, histological and micro-CT abnormalities, ER stress markers, NLRP3 inflammasome activation, TLR4 expression, dendritic cell infiltration and nuclea…
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